Born to poor parents, he lived a simple life, serving as a sacristan in the local church. He remained so until persuaded to invest in a trading venture. When the ship carrying the cargo in which he had invested sank in the harbour, Guy believed he was being punished for being greedy and went on a pilgrimage, first to Rome as penance, and then to Jerusalem where he worked as a guide to other pilgrims. He died on his way home.
He is the patron saint of Anderlecht, animals with horns, bachelors, convulsive children, epileptics, labourers, protection of outbuildings, protection of sheds, protection of stables, sacristans, sextons and work horses.